Today’s PrizePicks best picks and props of the day all come from a loaded slate of MLB action. The NBA playoffs are on hold tonight, so all of these PrizePicks predictions will come from the baseball world.

Casey Mize UNDER 4.5 Hits Allowed

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May 21, 2026; Detroit, Michigan, USA; Detroit Tigers pitcher Casey Mize (12) pitches in the first inning against the Cleveland Guardians at Comerica Park. Mandatory Credit: Rick Osentoski-Imagn Images

Casey Mize has been great this season, and he hasn’t allowed more than four hits in his last five starts. He faces the Los Angeles Angels on Wednesday, one of the worst lineups in the MLB. They average just over seven hits a game, the third worst in the MLB. Angels’ hitters have not had much success against Mize either. Mike Trout, Jorge Soler, and Jo Adell are a combined 2-25 in this matchup. Mize should also have a good fantasy score line when PrizePicks releases them.

Gerrit Cole OVER 4.5 Strikeouts

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May 22, 2026; Bronx, New York, USA; New York Yankees starting pitcher Gerrit Cole (45) pitches against the Tampa Bay Rays during the fifth inning at Yankee Stadium. Mandatory Credit: Brad Penner-Imagn Images

Gerrit Cole made his season debut on May 22nd, going six innings and throwing 72 pitches. His workload will rise again, making this 4.5 strikeouts line on PrizePicks an interesting one. The Kansas City Royals rank in the top ten in strikeouts, so he should go over this line pretty easily.

Bryce Elder UNDER 2.5 ERA

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May 22, 2026; Atlanta, Georgia, USA; Atlanta Braves pitcher Bryce Elder (55) in action against the Washington Nationals in the second inning at Truist Park. Mandatory Credit: Brett Davis-Imagn Images

Bryce Elder has only allowed three runs in three starts this season and has yet to allow any more than that. The Boston Red Sox are the second-worst team in the league when it comes to runs per game this season. They were one of the teams to tag Elder for three runs a couple of weeks ago, but it would be difficult to replicate that performance.

End Of My PrizePicks Rant

Today’s PrizePicks POTD is Cole. Pair him with Elder for the best 3x on today’s PrizePicks board. Remember to always bet responsibly; nothing should ever be considered a guarantee or lock.

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