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Chiefs Edge Staff Score Predictions: Week One

The Chiefs will open their 2022 regular season this Sunday against the Arizona Cardinals. With the game fast approaching, our writers give their score predictions for the upcoming matchup!

Kansas City opens its 2022 season against the Cardinals this Sunday. The game — kicking off at 3:25 central on Sunday — will be on CBS with Tony Romo and Jim Nantz on the call. Last season’s Cardinals saw a fairly up-and-down schedule. They started their season 7-0 and ultimately made their way to 10-2 before losing four of their final five games. The team finished second in the NFC West and lost their first playoff matchup to the eventual Super Bowl Champion Rams.

We’ve given our bold predictions for week one. Now, here are our staff score predictions for this weekend’s week one matchup!

Chiefs Edge Staff Predictions For Week One Against The Cardinals

Britt Zank, Contributing Writer – KC 38, ARI 23

Kansas City wins 38-23. The Chiefs’ offense dominates from start to finish. The young defense has its ups and downs but shows promise in a dominating win in Arizona.

Brycen Ellis, Contributing Writer – KC 38, ARI 24

After starting last season slow offensively, the Chiefs will look to come out the gate hot and fast in week one against the Cardinals. With the new offense and improved defense, I see Kansas City handling this game without much stress. Final Score Chiefs 38 Cards 24


Devin Hoover, Contributing Writer and Podcast Host – KC 35, ARI 21

The Cardinals’ defense isn’t going to stop the Chiefs, and I expect not having Deandre Hopkins will also hurt the Cardinals. Kansas City will get to test out their new offense, but I expect some growing pains with the defense. I expect at least one explosive play from the Cardinals, but in the end, it won’t be enough.

Mark Larison, Contributing Writer – KC 37, ARI 21

The Chiefs win the game 37 to 21. The Cardinals have a laundry list of injuries on their injury report. They don’t have film on the new Kansas City offense. Operation scorched earth for Patrick Mahomes has to begin somewhere.

Preston Farr, Managing Editor – KC 28, ARI 10

Much like in years past, the Chiefs offense will likely be pretty vanilla in week one against a weakened Cardinals roster. Deandre Hopkins is suspended for the first six games of the season and second-year wideout Rondale Moore suffered an injury in practice this week. Zach Ertz is also banged up as well. With such a decimated offense, Kansas City should handle business well. This will allow the offense to win early and coast through the second half.

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