These NFL Week 4 best bets are the top three picks for this Sunday’s slate of action. The Dallas Cowboys look to bury the Houston Texans on the road, while the Tampa Bay Buccaneers attempt to prove they are underestimated against the struggling Green Bay Packers. The San Francisco 49ers have been leaving a trail of destruction in their wake, and hope to take the Denver Broncos out to pasture this weekend. Please review the reasoning below, and remember to bet only disposable income.
The 0-3 Texans will host the 1-2 Cowboys on Sunday afternoon at Reliant Stadium, with both teams trying to get their train back on the tracks. Houston’s offense must be concerning to fans, averaging just 18.0 PPG, which is also inflated by some Week 1 hijinks, in which they shocked the world by scoring 31 points.
The Cowboys’ offense, on the other hand, has been the team’s strength, averaging 29.3 PPG entering Week 4. The combination of Dallas’ offensive production and the Texans’ struggling pass defense makes the Cowboys’ +138 moneyline particularly interesting at this price.
The Texans have the edge on defense, but it’s far too dull to offset their massive offensive shortcomings. Their pass defense has been an issue, ranking 26th so far. That said, who could blame one for finding some prop bets involving pieces like Cowboys quarterback Dak Prescott or wide receivers CeeDee Lamb and George Pickens? RotoWire reports one can get Prescott’s passing-yard total at 266.5 and Lamb’s receiving-yard total at 77.5, with both players going over those marks in each of their last two games.
The 1-2 Packers are one of the biggest disappointments in the NFL so far this season and are on fade alert until further notice. Their offense is averaging only 18.7 PPG, and the team has a 0-3 record against the spread in 2026. The 0-3 Buccaneers are far from perfect, but they’ve at least shown their fanbase glimmers of hope on the treasure map. Their sixth-ranked defense has kept them in games, with an average scoring margin six points better than their opponents.
This might just be the fishiest spread of the week. The 3-0 49ers are averaging 32.7 PPG through Week 3, second in the NFL behind only the Buffalo Bills, who are averaging just one more point per game. The 2-1 Broncos’ offense hasn’t been as kind to their fans, averaging just 20.0 PPG. Furthermore, San Francisco’s scoring defense ranks third, at 16.7 PPG, while Denver’s 23.3 PPG ranks them 17th. There is also a glaring difference in production when comparing quarterbacks Bo Nix and Brock Purdy. The following comparison highlights the statistical gap between Purdy and Nix through three weeks.
Those were the NFL Week 4 best bets for Sunday’s card of games. Please remember always to gamble responsibly. If things go as planned, Prescott will light up the Texans like a Christmas tree, and the Packers’ cheese will keep molding disgustingly. Purdy and the 49ers continuing their underappreciated dominance of the NFL would be the perfect cherry on top.
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